Midline malignant reticulosis (so‐called lethal midline granuloma)

Abstract

“Lethal midline granuloma” should be only a clinical term for rapidly evolving destructive lesions of the nose and the deep facial tissues. Such clinical presentation—after specific infections and carcinomas have been excluded—may occur in 3 different clinicopathologic entities: midline malignant reticulosis (polymorphic reticulosis), Wegener's granulomatosis, and malignant lymphoma of one of the accepted histologic types. One representative case of each of these is reported here, histologic criteria for differential diagnosis are outlined, and the literature is reviewed. Midline malignant reticulosis is defined as a lymphoproliferative disorder involving initially the nasal and the paranasal soft and bony parts and capable of later dissemination. Treatment should be based on the pathologic diagnosis made on viable biopsy tissue. Midline malignant reticulosis may have a better prognosis than malignant lymphoma of the nasal cavity when treated with tumoricidal doses of irradiation. On the other hand, Wegener's granulomatosis may respond to immunosuppresive drugs. Copyright © 1969 American Cancer Society