Unresolved issues and controversies in purinergic signalling

Abstract

Some areas of current interest in the rapidly expanding purinergic signalling field that are controversial or are unresolved are highlighted in this review. These include the mechanisms underlying: ATP transport across cell and vesicle membranes; the interaction of multiple receptors for purines and pyrimidines on single cells; the blocking effect of antagonists to P2X4 and P2X7 receptors expressed by microglial cells in neuropathic and inflammatory pain; and the complex actions mediated by P2X7 receptors. Some desirable areas for further research are also discussed including: comparative studies of the evolution of purinergic signalling; studies of purinergic signalling in development and regeneration, including the involvement of stem cells; behavioural studies; and therapeutic strategies. © 2008 The Author. Journal compilation © 2008 The Physiological Society.