Unpicking the combination lock for mutant BRAF and RAS melanomas

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Abstract

Large-scale, unbiased combinatorial drug screening has been used to identify effective genotypeselective therapeutic combinations that show promising activity in preclinical models of mutant BRAF and RAS melanoma that are resistant to the clinical BRAF inhibitor vemurafenib. © 2012 American Association for Cancer Research.

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Al-Lazikani, B., & Workman, P. (2013). Unpicking the combination lock for mutant BRAF and RAS melanomas. Cancer Discovery, 3(1), 13–19. https://doi.org/10.1158/2159-8290.CD-12-0520

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