Carbon–carbon bond formation and green chemistry: one dream and 30 years hence

Abstract

Carbon–carbon bond formation is the core of organic synthesis, in which organometallic reagents play the key role in the forms of 1,2-nucleophilic additions, conjugate additions, and transition-metal catalyzed cross-couplings. These reactions have enabled the production of a wide range of organic molecules in our society. Despite the enormous power of organometallic reagents in chemical synthesis, they have inherent drawbacks in the eyes of future sustainability. This account summarizes our efforts over the past three decades on the exploration of new scientific means to overcome the drawbacks and limitations of these classical organometallic reactions.