Depressed heart rate variability and arterial baroreflex in conscious transgenic mice with overexpression of cardiac G(sα)

Abstract

Recently, we developed a transgenic mouse with cardiac-specific G(sα) overexpression (TG mouse), which exhibits enhanced postsynaptic β-adrenergic receptor signaling, ultimately developing a cardiomyopathy. The goal of the present study was to determine whether cardiac G(sα) overexpression alters autonomic cardiovascular control, which could shed light on the mechanism responsible for the later development of cardiomyopathy. Mean arterial pressure was increased (P