Lipids and all-cause mortality among older adults: A 12-year follow-up study

Abstract

This is a 12-year follow-up cohort study with 800 people (6085 years old). The association between lipid disorders and mortality was analysed by Cox proportional hazard adjusted model. All-cause mortality was considered the dependent variable, and lipid disorders as independent variables: total cholesterol (TC) 200 and 170mg/dl, HDL-c 35 and 40, LDL-c 100 and 130, and triglycerides (TG) 50. An initial analysis of all subjects was performed and a second was carried out after having excluded individuals with a body mass index (BMI) 20kg/m2 or mortality in ≤2 years. The mortality showed a positive association with low TC and a negative association with high TC and high LDL-c. After the exclusion of underweight and premature mortality, there was a positive association only with TC 170mg/dl (HR = 1.36, CI95: 1.021.82). The data did not show a higher risk with high levels of TC, LDL-c, and TG. However, they showed higher mortality among older adults with low TC. Copyright © 2012 Marcos Aparecido Sarria Cabrera et al.