Dual catalysis with copper and rhenium for trifluoromethylation of propargylic alcohols: Efficient synthesis of α-trifluoromethylated enones

Abstract

Trifluoromethylation of propargylic alcohols to provide (Z)-α-trifluoromethylated enones and β-unsubstituted α-trifluoromethylated enones proceeded with high yield and selectivity in the presence of CuI/Re2O7. The Z isomer was formed under kinetic control, though it is less stable than the E isomer in terms of steric repulsion.