Cell-type specific burst firing interacts with theta and beta activity in prefrontal cortex during attention states

Abstract

Population-level theta and beta band activity in anterior cingulate and prefrontal cortices (ACC/PFC) are prominent signatures of self-controlled, adaptive behaviors. But how these rhythmic activities are linked to cell-type specific activity has remained unclear. Here, we suggest such a cell-to-systems level linkage. We found that the rate of burst spiking events is enhanced particularly during attention states and that attention-specific burst spikes have a unique temporal relationship to local theta and beta band population-level activities. For the 5-10 Hz theta frequency range, bursts coincided with transient increases of local theta power relative to nonbursts, particularly for bursts of putative interneurons. For the 16-30 Hz beta frequency, bursts of putative interneurons phase synchronized stronger than nonbursts, and were associated with larger beta power modulation. In contrast, burst of putative pyramidal cells showed similar beta power modulation as nonbursts, but were accompanied by stronger beta power only when they occurred early in the beta cycle. These findings suggest that in the ACC/PFC during attention states, mechanisms underlying burst firing are intimately linked to narrow band population-level activities, providing a cell-type specific window into rhythmic inhibitory gating and the emergence of rhythmically coherent network states during goal directed behavior.