One of hypothetical mechanisms related to cognition is exercise-induced IGF-1. Objective: The aim of this study was to analyze the effects of exercise on IGF-1 levels and cognition in the elderly. Methods: The article searches were conducted on Pubmed, Web of Science, PsycINFO and Scielo databases and reviewed according to PRISMA guidelines. The inclusion criteria were: [1] original articles published up to 2017; [2] samples including elderly; [3] protocols including physical exercise; [4] longitudinal studies having exercise as main outcome; [5] assessment of IGF-1; [6] cognition assessment. Results: Seven studies were included in this review. Three of the studies showed an exercise-induced increase in IGF-1; three found stable IGF-1 levels and one found a reduction in IGF-1; with and without improvement in cognition. Conclusion: Disparities in the type of physical exercise, protocols and samples under different conditions hinder the establishment of a consensus on IGF-1, cognition and physical exercise.
CITATION STYLE
Stein, A. M., Silva, T. M. V., Coelho, F. G. de M., Arantes, F. J., Costa, J. L. R., Teodoro, E., & Santos-Galduróz, R. F. (2018). Physical exercise, IGF-1 and cognition: A systematic review of experimental studies in the elderly. Dementia e Neuropsychologia, 12(2), 114–122. https://doi.org/10.1590/1980-57642018dn12-020003
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