The long-term treatment of hypertension with thiazide diuretics

Abstract

Two hundred and twenty-seven cases of moderate to severe hypertension were treated with thiazide diuretics alone for periods of up to 12 years. In 80%. the hypertension was adequately controlled without additional antihypertensive agents. Hypokalaemic alkalosis was common despite potassium supplements-but caused no symptoms. The incidence of diabetes and gout was low. It is concluded that thiazide diuretics provide excellent control of hypertension with very few side effects.