Amination of aryl iodides using a fluorous-tagged ammonia equivalent

Abstract

A fluorous-tagged ammonia equivalent for the Cu-catalyzed amination of aryl iodides is described in which N-Boc-protected anilines are produced in high overall yield and purity. All purification steps are performed using Fluorous SolidPhase Extraction (F-SPE) greatly simplifying and speeding up the isolation of the desired products. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Wemheim.