Cytotoxicity and molecular docking studies of a novel enaminone and its cadmium (II) complex

Abstract

The anti-cancerous potential of novel Enaminone and its Cadmium complex was estimated by measuring its cytotoxicity for human breast cancer cell line (MCF-7). Both compounds PFA and PFA-Cd were prepared and subsequently characterized by FTIR, ICP-AES, UV-Vis, TGA, 1 H NMR, 13 C NMR and FAB-MS. The results were in great consistency with the structures of the both compounds. Furthermore, the ligand and its metal complex were screened for their cytotoxicity against human cancer cell lines. It was found that the compound PFA was more active anti-cancerous agent as compared to PFA-Cd. Molecular Docking studies were carried out to found the predominate binding mode of synthesized compound in the vicinity of double helical DNA structure.