The relationship between IGF2BP2 and PPARG polymorphisms and susceptibility to esophageal squamous-cell carcinomas in the eastern Chinese Han population

Abstract

The aim of this case–control study was to assess whether PPARG and IGF2BP2 polymorphisms confer susceptibility to esophageal squamous-cell carcinoma (ESCC). A total of 507 patients pathologically confirmed for ESCC and 1,496 age-, sex-, and residence-matched healthy individuals were enrolled. The PPARG rs1801282 C˃G and rs3856806 C˃T and IGF2BP2 rs1470579 A˃C and rs4402960 G˃T polymorphisms were selected and genotyped by SNPscan genotyping assays. Multivariable logistic analysis suggested that the PPARG rs3856806 C˃T polymorphism might increase the risk of ESCC. In different stratified analyses, there were significant associations between PPARG rs3856806 C˃T and risk of ESCC in female, never-smoking, drinking, and never-drinking subgroups. In addition, we also found that PPARG rs1801282 C˃G increased ESCC risk in the never-smoking subgroup. There was significant difference in Crs1470579Grs4402960Crs1801282Crs3856806-haplotype distribution among ESCC cases and control subjects. In conclusion, our findings highlight that PPARG rs1801282 C˃G and rs3856806 C˃T polymorphisms are candidates for susceptibility to ESCC in the eastern Chinese Han population. The Crs1470579Grs4402960Crs1801282Crs3856806 haplotype is associated with susceptibility to ESCC.