The effect of non-activated prothrombin complex concentrate (Proplex® ST) on intraperitoneal hematoma in a hemophilia A patient with a factor VIII inhibitor

Abstract

A 28-year-old severe hemophiliac with a factor VIII inhibitor was admitted to our hospital with a massive and serious intraperitoneal hematoma. He was a high-responder patient showing maximal serum inhibitor levels as high as 255 Bethesda Units/ml (BU/ml). He was successfully treated with 'bypass therapy' using a prothromhin complex concentrate (PCC).