Evaluation of the anti-inflammatory action of curcumin analog (DM1): Effect on iNOS and COX-2 gene expression and autophagy pathways

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Abstract

This work describes the anti-inflammatory effect of the curcumin-analog compound, sodium 4-[5-(4-hydroxy-3-methoxyphenyl)-3-oxo-penta-1,4-dienyl]-2-methoxy-phenolate (DM1), and shows that DM1 modulates iNOS and COX-2 gene expression in cultured RAW 264.7 cells and induces autophagy on human melanoma cell line A375.

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Paulino, N., Paulino, A. S., Diniz, S. N., De Mendonça, S., Gonçalves, I. D., Faião Flores, F., … Quincoces Suarez, J. A. (2016). Evaluation of the anti-inflammatory action of curcumin analog (DM1): Effect on iNOS and COX-2 gene expression and autophagy pathways. Bioorganic and Medicinal Chemistry, 24(8), 1927–1935. https://doi.org/10.1016/j.bmc.2016.03.024

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