New dihydro-β-agarofuran sesquiterpenes from parnassia wightiana wall: Isolation, identification and cytotoxicity against cancer cells

Abstract

Five new 4-8) and three known 1-(3) dihydro-β-agarofuran sesquiterpene polyesters were isolated from the whole plants of Parnassia wightiana. The structures of all compounds were elucidated through spectroscopic analysis including 2D-NMR and HR-MS. The absolute configuration of these compounds was established by X-ray diffraction analysis, comparison of NOESY spectra and biogenetic means. The cytotoxities of compounds 2-8 were evaluated in vitro against HL-60, SMMC-7721, A549, MCF-7 and SW480 cell lines. Compounds 5-7 exhibited the highest activities with IC50 values of 11.8-30.1 μM in most cases. The SAR revealed that theintroduction of hydroxyl group was able to signific lyt improve the activities of the compounds for most of the cell lines. © 2014 by the authors; licensee MDPI, Basel, Switzerland.