Studies on cross-resistance between capreomycin and certain other anti-mycobacterial agents

Abstract

Capreomycin, originally called capromycin, is a new antibiotic which was isolated from Streptomyces capreolus in the laboratories of Eli Lilly & Co. Herr et al. (1961, 1962) reported that this peptide antibiotic, with a molecular weight of approximately 740, was active primarily against Mycobacteria, and cross-resistance was not recognized between capreomycin and streptomycin or viomycin in vitro. On the other hand, Robinson and Wichelhausen (1962) noted some differences in the susceptibility to capreomycin of the wild strains tested. These reports, however, did not include a detailed analysis of the cross-resistance with capreomycin. This paper presents results of cross-resistance experiments on capreomycin and some clinically important antimycobacterial agents, employing human tubercle bacilli and M. phlei. © 1963, National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee. All rights reserved.