A randomised clinical trial comparing 2% econazole and 5% natamycin for the treatment of fungal keratitis

Abstract

Aim: To compare 2% econazole and 5% natamycin in the management of fungal keratitis. Methods: A randomised clinical trial was performed using 2% econazole or 5% natamycin as the two treatment arms on patients presenting with culture positive fungal keratitis to the cornea service at Aravind Eye Care System, Madurai, India. Results: 116 patients were recruited, and 112 continued in the study. There were no significant differences between the two arms at baseline or for success (defined as a healed or healing ulcer) at final visit (p=0.79). Conclusions: 2% Econazole appears to be as effective as 5% natamycin for the management of fungal keratitis.