The correlation between the indonesian version of montreal cognitive assessment and homocysteine levels in bataknese male with schizophrenia in prof. Dr. m. ildrem psychiatric hospital medan

Abstract

BACKGROUND: The pathogenesis of schizophrenia and its mechanism is not convinced. Several studies indicate that schizophrenia pathogenesis can be related to changes at the cellular level. The studies show homocysteine in people with schizophrenia was significantly increased, abnormal homocysteine metabolism can lead to DNA methylation. AIM: This study aimed to establish the correlation between the Indonesian Montreal Cognitive Assessment Version (MoCA-Ina) scores and homocysteine levels in males with Bataknese schizophrenia. METHODS: This study is a numerical correlative analytic study with an approach to cross-sectional study; by evaluating the correlation between the MoCA-Ina scores and the level of homocysteine in males with Bataknese schizophrenia. RESULTS: The median of the MoCA-Ina score in the study subjects was 22, with a minimum score of 18 and a maximum score of 26. There was a significant correlation between the MoCA-Ina scores and Homocysteine levels (p = 0.001). CONCLUSION: The interpretation obtained from this study is that the higher Homocysteine level, the lower the MoCA-Ina scores in Bataknese men with schizophrenia is.