Efficacy of preoperative administration of paracetamol-codeine on pain following impacted mandibular third molar surgery: A randomized, split-mouth, placebo-controlled, double-blind clinical trial

Abstract

Objectives.The aim of this study was to determine the effectiveness of preoperative administration of single-dose of paracetamolcodeine, in the relieving of acute postoperative pain after the surgical removal of an impacted mandibular third molar. Materials and Methods.The study cohort consisted of 32 Caucasian outpatients, giving a total of 64 bilateral symmetrical impacted mandibles. Patients were randomized in two experimental groups to receive a preoperative oral dose of paracetamol-codeine (analgesic group) or a placebo (placebo group) at the first and second surgeries. Study participants were asked to record pain intensity scores during the operation and the next 2 days, the time of the first request for rescue analgesic, and the total number of postoperative-supplement paracetamol-codeine tablets. Results. The pain intensity score on the first day was significantly lower in the analgesic group than in the placebo group (P < 0.001).The time to using rescue therapy was significantly longer in the analgesic group than in the placebo group (P = 0.004). The number of paracetamol-codeine tablets used postoperatively did not differ between the analgesic and placebo groups (P = 0.104). Conclusions. Preoperative paracetamol-codeine is effective in providing immediate postoperative pain control after third molar surgery and in delaying the initial onset of pain. This trial is registered with ClinicalTrials.gov Identifier (Registration Number): NCT03049878.