Abstract
Interactions of three new isophorone derivatives, Isoa Isob and Isoc with salmon testes DNA have been investigated using UV-Vis, fluorescence and circular dichroism spectroscopic methods. All the studied compounds interact with DNA through intercalative binding mode. The stoichiometry of the isophorone/DNA adducts was found to be 1:1. The fluorescence quenching data revealed a binding interaction with the base pairs of DNA. The CD data indicate that all the investigated isophorones induce DNA modifications.
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CITATION STYLE
Deiana, M., Matczyszyn, K., Massin, J., Olesiak-Banska, J., Andraud, C., & Samoc, M. (2015). Interactions of isophorone derivatives with DNA: Spectroscopic studies. PLoS ONE, 10(6). https://doi.org/10.1371/journal.pone.0129817
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