In silico-modelling of phytochemicals in septic arthritis

Abstract

Septic arthritis is a serious medical condition associated with severe morbidity and mortality. However, the clinical manifestations can be broad with conditions that resemble this synovial infection and require different assessment and care. Septic arthritis generally manifests with monoarticular joint pain with urticaria, swelling with pain on lesion and movement. Fever is present in many cases, but most are usually mild. Diagnostic tests can assist with the treatment, but the standard procedure to cure this infection is Arthrocentesis or joint aspiration. The management of septic arthritis includes intravenous antibiotics by intermittent infusion and orthopedic incisions. This descriptive research work discusses the in silico docking studies by using phytochemicals like Andrographolide, Capsaicin, Curcumin, Epigallocatechin gallate, Eugenol, Gingerol, Thymoquinone, Piperine with Proteins with PDB id's 2MZW, 1TVF, 1VQQ, and 3VSL respectively and could display anti-arthritic activity against the host-pathogen like Staphylococcus aureus which is the primary pathogen that causes in the pathogenesis of septic arthritis. Clearly, these phytochemicals should be further examined in preclinical and clinical trials to validate their effective efficacy against the disease.