Preparation of β-aminoesters from ketene silyl acetals and N-(alkylamino)benzotriazoles

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Abstract

A wide variety of β-aminoesters are prepared in good yields by the reaction of lithium ester enolates derived from ketene silyl acetals with N-(alkylamino)benzotriazoles. The secondary β-aminoesters readily cyclize to β-lactams (2-azetidinones) on deprotonation. © 1990.

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Katritzky, A. R., Shobana, N., & Harris, P. A. (1990). Preparation of β-aminoesters from ketene silyl acetals and N-(alkylamino)benzotriazoles. Tetrahedron Letters, 31(28), 3999–4002. https://doi.org/10.1016/S0040-4039(00)94482-4

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