Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) in Type 2 Diabetes Mellitus, a Case Control Study

Abstract

The present study observed a significant association between Type 2 Diabetes mellitus and coagulation parameters. Increased plasma levels of PT and APTT were observed which are consistent with abnormal coagulation mechanisms and may be interpreted as a tendency for bleeding and cardiovascular disorders. Diabetes mellitus is a heterogeneous disorder that affects cellular metabolism in variety of ways and coagulation indices are reported to be adversely affected. As Diabetes mellitus is a complex disorder, its complications should be monitored closely. As it is rightly said that Diabetes is a "double edge sword", which can result in thrombo-embolic or hemorrhagic complications. Thus, coagulation parameters should be closely monitored and should be a part of test requested by the clinicians in diabetes mellitus because of its attendant risk to various complications such as atherosclerosis, stroke, etc. Prothrombin time (PT) and activated partial thromboplastin time (APTT) are haematological indices that give an idea about the coagulation status of patients. These observations made in our study can contribute in better understanding of relationship between Diabetes mellitus, coagulation profile. It would also be helpful to incorporate coagulation screening as a routine investigations for the better management of diabetic patients.