Chemical Synthesis, Characterization of Ag, Au Nanoparticles and Formulation of Bimetallic Nanostructure onto Tri-block Copolymer Surfaces

Abstract

Silver and gold nanoparticles (AgNPs and AuNPs) and bimetallic nanoparticles Poloxamer-P407 solvated (Ag/Au-P407) target various fields due to particle morphology, small size and unique physical and chemical properties. In this study, the NPs preparations by chemical reduction were thermally assisted. Unlike a central core/shell’s type system of the Ag/AuP407 has formed a solvated copolymer of tri-block type (P407). The aim of this strategy of synthesis and formulation of monometallic and bimetallic nanoparticles was to evaluate the temperature and time effect on the surface plasmon resonance, shape, size, zeta potential, nature crystalline, enthalpy changes, elemental analyses, and morphology. The chemical, physicochemical, and morphological proprerties have been conducted by spectroscopy, calorimetry (DSC), dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA), high-resolution microscopy (SEM, ATM, AFM) and X-Ray dispersive energy. AgNPs, AuNPs and Ag/Au NPs onto P407 copolymer surfaces have successfully been obtained and showed high-grade nanoparticles’ stability; then, they are now ready to be assessed as a therapeutic system.