The Relationship between the Level of Glycosylated hemoglobin (HbA1c) with The Incidence Rate of Diabetic Foot in H. Adam Malik General Hospital

Abstract

Background : Diabetes Mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia that occurs due to insulin secretion abnormalities, insulin work or both. Most Diabetes Melitus treatments are always associated with diabetic ulcers. Death rates and amputation rates are still high, respectively at 32.5% and 23.5%. The fate of patients with post-amputation Diabetes Melitus is still very bad, as many as 14.3% will die within a year after amputation and 37% will die 3 years after amputation. It has been  mentioned in previous clinical studies that uncontrolled diabetes mellitus was associated with elevated HbA1c  levels associated with the development of retinopathy as well as other complications, with a research reference value r = 0.079. Methods : The study involved Diabetes Melitus patients with diabetic foot diagnosis in Thoracic, Cardiac, and  Vascular  Surgery Polyclinic Department of Surgical and Inpatient Surgery RSUP H. Adam Malik Medan  period  January 2014- December 2016 with a total sample of 70 people. Result : The mean age of study subjects was 55.65 + 12.25. In the table shows that the study subjects based on the most gender were men with 47 subjects (67%). The mean of Glycosilated hemoglobin (HbA1c) was 6.4 + 2.44 mg / dL with the most patients found  at HbA1c <7 mg / dL level of  49 patients (70%). The result of the analysis is p = 0.0001 (p <0,05) this means there is significant relation between Glycosilated hemoglobin (HbA1c) and diabetic foot. Also obtained OR = 3.1 (CI = 95%, p <0.05). Conclusion: Bivariatically there was a significant correlation between Glycosilated hemoglobin (HbA1c) and diabetic foot with p = 0.0001 and Odd Ratio of OR = 3,1 (CI = 95%, p <0,05). For the mean result of Glycosilated hemoglobin (HbA1c) was 6.4 + 2.44 mg / dL with the highest HbA1c <7 mg / dL of 49 patients (70%).