Primary pleomorphic liposarcoma of liver: A case report and review of the literature

Abstract

Pleomorphic liposarcoma is an uncommon form of liposarcoma that rarely occurs in liver, especially the primary pleomorphic liposarcoma of liver. In the current work, we presented a case of primary pleomorphic liposarcoma of liver in a 43-year-old male with the history of abdominal tumor. Microscopically, the tumor consisted of pleomorphic spindle shaped tumor cells and fascicles of spindled and smaller, round cells admixed with multinucleated giant cells. Immunohistochemical staining of Vimentin, S-100 and p53 were positive, also, the tumor had a higher mean Ki-67 proliferation index. Other markers including pan-CK, CK18, CAM5.2, CDX-2, Villin, EMA, CD34, SMA, CD117, CD68, lysozyme, AFP, HMB45, HBsAg and HBcAg were all negative staining. We also reviewed this tumor in different organs which have been published in the literature.