Thwarting galectin-induced immunosuppression in breast cancer

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Abstract

Novel therapeutic strategies are needed to counteract breast cancer-associated immunosuppression. Silencing the expression of galectin-1 in a breast carcinoma model inhibited tumor growth and prevented lung metastasis by reducing the frequency and immunosuppressive activity of CD4+CD25+ FOXP3+ regulatory T cells. © 2013 Landes Bioscience.

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Salatino, M., Dalotto-Moreno, T., & Rabinovich, G. A. (2013). Thwarting galectin-induced immunosuppression in breast cancer. OncoImmunology, 2(5). https://doi.org/10.4161/onci.24077

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