Mathematical Modeling and Analysis of Tumor Chemotherapy

Abstract

Cancer diseases lead to the second-highest death rate all over the world. For treating tumors, one of the most common schemes is chemotherapy, which can decrease the tumor size and control the progression of cancer diseases. To better understand the mechanisms of chemotherapy, we developed a mathematical model of tumor growth under chemotherapy. This model includes both immune system response and drug therapy. We characterize the symmetrical properties and dynamics of this differential equation model by finding the equilibrium points and exploring the stability and symmetry properties in a range of model parameters. Sensitivity analyses suggest that the chemotherapy drug-induced tumor mortality rate and the drug decay rate contribute significantly to the determination of treatment outcomes. Numerical simulations highlight the importance of CTL activation in tumor chemotherapy.