Epstein-Barr virus renders the infected natural killer cell line, NKL resistant to doxorubicin-induced apoptosis

Abstract

We established two Epstein-Barr virus (EBV)-infected NKL sublines, which acquired stress resistant phenotype against DNA damage and starvation compared with EBV-negative NKL. EBV-rendered doxorubicin resistance at least partially through NF-κB activation and the resultant sustenance of antiapoptotic proteins including Bcl-XL and FLIPL/S. © 2008 Cancer Research.