Abstract
Three new lignans, longipedunins A (1), B (2) and C (3), together with three known compounds, benzoyl-binankadsurin A (4), acetyl-binankadsurin A (5) and schisanlactone A (6), were isolated from Kadsura longipedunculata. Their structures and stereochemistry were determined by spectral and single-crystal X-ray analyses. Compounds 1 and 6 showed appreciable inhibitory activity against HIV-1 protease with IC50 values of 50 and 20 μM, respectively. © 2006 Pharmaceutical Society of Japan.
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Sun, Q. Z., Chen, D. F., Ding, P. L., Ma, C. M., Kakuda, H., Nakamura, N., & Hattori, M. (2006). Three new lignans, longipedunins A-C, from Kadsura longipedunculata and their inhibitory activity against HIV-1 protease. Chemical and Pharmaceutical Bulletin, 54(1), 129–132. https://doi.org/10.1248/cpb.54.129
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