Evaluation of Nephroprotective Activity of Hydroalcoholic Extract of Trachyspermum ammi Leaves and Citrus paradisi Fruits against Prednisolone Induced ADPKD in Experimental Rats

Abstract

The study evaluated the nephroprotective activity of hydroalcoholic extracts of Trachyspermum ammi leaves and Citrus paradisi fruits against prednisolone-induced ADPKD in experimental rats. The hydroalcoholic extracts were given orally at 100 and 200 mg/kg for a period of 28 days. Kidney function was evaluated by measuring serum and urine creatinine, urea, uric acid, and proteinuria. Histopathological studies were also conducted. Materials and methods: Animal model was used to evaluate the nephroprotective effect of hydroalcoholic extract from T. ammi leaves & C. paradisi fruits against prednisolone induced ADPKD in Wistar rats. Keywords: Trachy spermum ammi leaves, Citrus pardisi fruit, Nephro protective activity, ADPKD, Prednisolone. International Journal of Drug Delivery Technology (2023); DOI: 10.25258/ijddt.13.2.25 How to cite this article: Varalakshmi TN, Chitra V. Evaluation of Nephroprotective Activity of Hydroalcoholic Extract of Trachyspermum ammi Leaves and Citrus paradisi Fruits against Prednisolone Induced ADPKD in Experimental Rats.