A test of a counting model for chiasma interference

Abstract

According to the model of FOSS, LANDE, STAHL, and STEINBERG, chiasma interference is a reflection of the requirement for crossovers to be separated by an organism-specific number of potential conversion events without associated crossovers. This model predicts that tetrads with close double crossovers should be enriched for conversion events that themselves are not associated with crossing over. We tested this prediction in Saccharomyces cerevisiae and found it to be unfulfilled.