AMPylation of rho GTPases subverts multiple host signaling processes

Abstract

Background: VopS is a bacterial effector that AMPylates Rho GTPases. Results: AMPylation of Rho GTPases inhibits their interaction with multiple downstream effectors. Conclusion: VopS conducts a multifaceted host signaling inhibition program by targeting the critical Rho GTPases. Significance: Broadens the understanding of how switch-1 modification of Rho GTPases affects host responses.