In vitro-Generation von Antikörpern mittels Phagen-Display

Abstract

Antibodies or immunoglobulins are of vital importance for the neutralization of foreign particles like pathogens in the body. As therapeutics, they provide a high potential for many diseases due to their high specificity. For their generation, the establishment of a library (immunized or synthetic) and a selection process for specific binders (display methods) play the pivotal role. Here, we describe the phage display technology and its advantages to get a specific and high affinity binder.