The synthesis of a series of Pd(II) (Pd-1–3) complexes including either salen or salphen ligands is described. All complexes were fully characterised by standard spectroscopic techniques. Complex Pd-3 was also characterised by single-crystal X-ray diffraction analysis, revealing the palladium center in Pd-3 to be in distorted square planar environment. In addition, the determination of the in vitro cytotoxic activity of the palladium complexes Pd-1–3 was evaluated against five human cancer cell lines including human glioblastoma (U-251), human prostatic adenocarcinoma (PC-3), human lung adenocarcinoma (SKLU-1), human gingival fibroblast (FGH) and human mammary adenocarcinoma (MCF-7). Being complex Pd-2 the best of the series when compared to cisplatin against human prostatic adenocarcinoma (PC-3) with a half maximal inhibitory concentration (IC50) of 3.8 ± 0.4 μM. These results were complemented with docking calculations.
CITATION STYLE
López-Sánchez, R., Roberto Pioquinto-Mendoza, J., González-Sebastián, L., Toscano, R. A., Flores-Alamo, M., Teresa Ramírez-Apan, M., … Morales-Morales, D. (2023). Synthesis and preliminary in vitro cytotoxic activity of Pd(II) complexes including Salen- or Salphen-Ligands. Inorganica Chimica Acta, 550. https://doi.org/10.1016/j.ica.2023.121450
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