Procalcitonin levels differences in preeclampsia and non-preeclampsia

Abstract

One of the main complications that cause maternal death is preeclampsia/eclampsia. Activation of the systemic inflammatory response is thought to play a role in the pathogenesis of preeclampsia. Urinary tract infections (UTI) can cause activation of the systemic inflammatory response so that it is considered capable of causing preeclampsia. Procalcitonin is known as a marker of infection and very stable in serum, so it is a promising biomarker in detecting UTI. The investigators intend to investigate the association between UTI and preeclampsia through the exploration of procalcitonin levels in preeclampsia and non-preeclampsia mothers. This study was a cross-sectional method, accident sampling technique. Respondents in this study amounted to 65, preeclampsia criteria were 40, and not preeclampsia was 25. The results showed no relationship between urinary tract infections during pregnancy and preeclampsia P = 0.074. Even so, procalcitonin levels in preeclampsia mothers were found to be higher than mothers without preeclampsia, with a value of P = 0.005. This means that the inflammation that occurs in preeclampsia mothers is not caused by urinary tract infections. It is hoped that further research can be carried out on the relationship between urinary tract infections and preeclampsia by using a larger sample.