Lipid A-Mediated bacterial–host chemical ecology: Synthetic research of bacterial lipid as and their development as adjuvants

10Citations
Citations of this article
12Readers
Mendeley users who have this article in their library.

Abstract

Gram-negative bacterial cell surface component lipopolysaccharide (LPS) and its active principle, lipid A, exhibit immunostimulatory effects and have the potential to act as adjuvants. However, canonical LPS acts as an endotoxin by hyperstimulating the immune response. Therefore, LPS and lipid A must be structurally modified to minimize their toxic effects while maintaining their adjuvant effect for application as vaccine adjuvants. In the field of chemical ecology research, various biological phenomena occurring among organisms are considered molecular interactions. Recently, the hypothesis has been proposed that LPS and lipid A mediate bacterial–host chemical ecology to regulate various host biological phenomena, mainly immunity. Parasitic and symbiotic bacteria inhabiting the host are predicted to possess low-toxicity immunomodulators due to the chemical structural changes of their LPS caused by co-evolution with the host. Studies on the chemical synthesis and functional evaluation of their lipid As have been developed to test this hypothesis and to apply them to low-toxicity and safe adjuvants.

Cite

CITATION STYLE

APA

Shimoyama, A., & Fukase, K. (2021, October 1). Lipid A-Mediated bacterial–host chemical ecology: Synthetic research of bacterial lipid as and their development as adjuvants. Molecules. MDPI. https://doi.org/10.3390/molecules26206294

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free