Electrochemical behaviour of benzofuran derivatives of pharmaceutical interest at solid electrodes

Abstract

The electrooxidation of four structually related drugs (amiodarone and benziodarone and their iodinated derivatives), has been studied, using cyclic voltammetry and controlled potential coulometry at carbon paste and platinum electrodes in hydro-organic media. The oxidative mechanisms have been suggested on the basis of a comparative study and by analyzing the ip, Ep/ pH plots, the number of electrons evolved and the cyclic voltammetric behaviours. The influence of carbon-iodine bonds on the redox pattern of the molecules has been analyzed and a comparison between the oxidation pattern of the phenolic molecules and the corresponding diethylaminoethoxy derivatives has been realized. Quantitative measurements have been obtained at the carbon paste electrode, within the range of concentrations 5. x 10-6M-5 x 10-5M. The analytical usefulness in determination of these compounds has been demonstrated. © 1986, Taylor & Francis Group, LLC. All rights reserved.