A cascade cyclization approach to schweinfurthin B

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Abstract

(graph presented) A strategy for synthesis of the hexahydroxanthene moiety of the natural products schweinfurthin A, B, and D is described. The relative stereochemistry in the key cationic cyclization step is established through the preference of the phenylselenide substituent for an equatorial orientation.

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Treadwell, E. M., Neighbors, J. D., & Wiemer, D. F. (2002). A cascade cyclization approach to schweinfurthin B. Organic Letters, 4(21), 3639–3642. https://doi.org/10.1021/ol0266368

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