An efficient synthesis of novel chromone-containing furopyrimidines

Abstract

The one-pot three-component reaction of 1,3-disubstituted barbituric acid derivatives, 3-formylchromones and alkyl isocyanides proceed smoothly at room temperature to give the corresponding chromone-containing furopyrimidines derivatives in good yields within 10 minutes in DMF. This three-component reaction represents a facile and efficient route to the furo[2,3-d]pyrimidine derivatives, which have become synthetic targets for many organic and medicinal chemists. In the course of the creation of a fused furopyrimidine ring, three bonds (C=C, C-C and C-O bonds) are newly formed.