Surface-engineered nanomaterials as X-ray absorbing adjuvant agents for Auger-mediated chemo-radiation

Abstract

We report a prototype approach to formulate gold nanoparticle-based X-ray absorbing agents through surface-engineering of a cisplatin pharmacophore with modified polyacrylate. The resulting agents exhibit both chemo-therapeutic potency to cancer cells and Auger-mediated secondary electron emission, showing great potential to improve the therapeutic efficacy of chemo-radiation. © 2013 The Royal Society of Chemistry.