The skeletal muscle metaboreflex: a novel driver of ventilation, dyspnoea and pulmonary haemodynamics during exercise in pulmonary arterial hypertension

Abstract

In summary, the novel findings of this study are that metaboreflex activation evokes exaggerated ventilatory and pulmonary vascular responses in PAH, and causes clinically meaningful increases in ratings of perceived dyspnoea. This study raises the possibility that metaboreflex afferents represent a novel physiological mechanism to target (e.g. pharmacologically or by exercise training) for improving exertional dyspnoea in PAH.