A convenient method for the synthesis of deoxyribonucleoside 3′-hydrogenphosphonates

Abstract

Appropriately protected 5′-O-dimethoxytrityldeoxyribonucleoside derivatives were converted to the corresponding 3′-hydrogenphosphonates by treatment with phosphinic acid in the presence of mesitylenedisulfonyl chloride via an oxidative phosphonylation process. © 1988.