The effect of monosodium glutamate (Msg) administration to pyramidal cells necrosis on cerebral cortex of wistar male rats (rattus norvegicus)

Abstract

Purpose – The objective of the present study was to determine the effect of monosodium glutamate (MSG) administration to pyramidal cells necrosis on the cerebral cortex of Wistar male rats (Rattus norvegicus). Design/Methodology/Approach – This research was a laboratory quasi-experiment study with posttest control group design on 24 male Wistar rats (Rattus norvegicus) aged 8-10 weeks, weighted 200 6 10 gr, divided into 4 groups (GI or control group, GII treated with MSG dose 6 mg/grbb/day, GIII 12 mg/grbb/day, and GIV 24 mg/grbb/day) for 21 days consecutively. Pyramidal cells observed in 10 field of view. The Kruskal-Wallis test and Mann Whitney tests were used to analyze the data. Findings – There were significant differences between pyramidal cells necrosis numbers between control and the treatment groups. MSG doses 6, 12, and 24 mg/grbb/day developed the pyramidal cells necrosis in the cerebral cortex (p < 0,005).