Asymmetric synthesis of (+)-febrifugine and (+)-isofebrifugine using yeast reduction

Yasuo Takeuchi; Kumiko Azuma; Kentaro Takakura; Hitoshi Abe; Hye Sook Kim; Yusuke Wataya; Takashi Harayama

Journal Article

Asymmetric synthesis of (+)-febrifugine and (+)-isofebrifugine using yeast reduction

Tetrahedron (2001) 57(7) 1213-1218

DOI: 10.1016/S0040-4020(00)01109-1

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Abstract

The antimalarial agents febrifugine (D-1) and isofebrifugine (D-2) were synthesized from chiral 3-piperidinol (D-4), which was asymmetrically prepared by the yeast reduction of 3-piperidone derivatives (DL-3), with dynamic optical resolution. © 2001 Elsevier Science Ltd.

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Takeuchi, Y., Azuma, K., Takakura, K., Abe, H., Kim, H. S., Wataya, Y., & Harayama, T. (2001). Asymmetric synthesis of (+)-febrifugine and (+)-isofebrifugine using yeast reduction. Tetrahedron, 57(7), 1213–1218. https://doi.org/10.1016/S0040-4020(00)01109-1

Asymmetric synthesis of (+)-febrifugine and (+)-isofebrifugine using yeast reduction

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