Enzyme Kinetic Equations of Irreversible and Reversible Reactions in Metabolism

Abstract

This paper compares the irreversible and reversible rate equations from several uni-uni kinetic mechanisms (Michaelis-Menten, Hill and Adair equations) and bi-bi mechanisms (single- and doubledisplacement equations). In reversible reactions, Haldane relationship is considered to be identical for all mechanisms considered and reversible equations can be also obtained from this relationship. Some reversible reactions of the metabolism are also presented, with their equilibrium constant.