Ultrasensitive Electrochemical Sensor for the Detection of Mefenamic Acid Based on Calcium Vanadate Nanofilaments/Reduced Graphene Oxide Nanocomposite

Abstract

In this work, we successfully developed the Ca10V6O25 (CVO) nanofilaments embedded reduced graphene oxide (RGO) nanocomposite by the facile hydrothermal method and fabricated on the surface of the working electrode (glassy carbon electrode-GCE), which is used for the detection of mefenamic acid (MFA). It is highly selective, more sensitive, and low-cost. Our hydrothermally prepared CVO/RGO nanocomposite was scrutinized by various spectroscopies. The electrical conductivity of the CVO nanofilaments was enhanced by the RGO nanosheets, which were established by EIS and CV analysis. our proposed CVO/RGO/GCE sensor displayed excellent sensitivity and selectivity for the detection of MFA. Furthermore, our proposed CVO/RGO/GCE sensor exhibited a low detection limit (LOD) of 0.0079 µM. Additionally, we scrutinized the practical application of our proposed CVO/RGO/GCE sensor towards MFA in the real samples (human blood serum and urine) which displayed good recovery results.