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Characterization of recombinant tetanus toxin derivatives suitable for vaccine development

Infection and Immunity
DOI: 10.1128/iai.63.8.3218-3221.1995
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Abstract

Recombinant derivatives of tetanus toxin (TeTx) were isolated and used to immunize mice. Recombinant TeTx light chain, a derivative of fragment C that had lost the ability to bind neurons, and a recombinant TeTx holotoxoid that could protect mice against TeTx challenge were identified.

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Figueiredo, D., Turcotte, C., Frankel, G., Li, Y., Dolly, O., Wilkin, G., … Dougan, G. (1995). Characterization of recombinant tetanus toxin derivatives suitable for vaccine development. Infection and Immunity. American Society for Microbiology. https://doi.org/10.1128/iai.63.8.3218-3221.1995

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