P4393The clinical characteristics of mortality in patients with Takotsubo Syndrome during hospitalization-A Multicenter Registry in Eight-University Hospitals in East Japan

Abstract

Background: The purpose of this study was to evaluate the clinical characteristics of mortality in patients with Takotsubo Syndrome (TS) during hospitalization. Methods: The study cohort consisted of 342 consecutive patients with TS in the each acute coronary syndrome registry of eight-university hospitals in east Japan (n=10,622). Patients were divided into the mortality group (n=32; 9.4%) and the survival group (n=310; 90.6%). We attempted to characterize clinical differences during hospitalization, comparing the mortality group and the survival group with TS. Results: There were 12 patients with cardiac death including cardiogenic shock, pump failure, oozing cardiac rupture and ventricular fibrillation and 20 patients with non-cardiac death. Male gender (40.6% vs. 18.7%; p<0.01) and the presence of physical or stress trigger (84.4% vs. 65.9%; p=0.03) were more common in the mortality group. There were no significant differences in age (71.6±11.2 years vs. 71.0±11.2 years; p=0.38), diabetes (13.3% vs. 16.9%; p=0.61), old myocardial infarction (0% vs. 1.0%; p=0.58), and psycho-neurologic disease (6.7% vs. 8.4%; p=0.61). While, carcinoma under treatment was more common in the mortality group (30.0% vs. 8.1%; p<0.01). Multivariate logistic regression analysis confirmed male (odds ratio 2.7; 95% CI: 1.2-6.0; p=0.02) was an independent predictor of mortality during hospitalization. Conclusion: Male patients with TS were associated with high mortality during hospitalization.